laboratory
Serine/Threonine protein kinases play
pivotal roles in the cellular signaling pathways that control the proliferation
and differentiation of eukaryotic cells. The cyclin-dependent kinases (CDKs),
which belong to this protein kinase family, are regulators of eukaryotic cell
cycle progression in cooperation with various endogenous cyclins and
cyclin-dependent kinase inhibitors. Achieving cell cycle control is an important
goal in the treatment of diseases characterized by uncontrolled cell
proliferation. Consequently, the CDKs could be important molecular targets for
such thera-peutic intervention, and inhibition of CDK activity may be
particulary useful in the treatment of cancer.
Apoptosis has been characterized as a
fundamental cellular event to maintain the physiological balance and
homeostasis of the organism. The relationship between dysregulation of
apoptosis and cancer formation has been emphasized, with increasing evidence
suggesting that the related processes of neoplastic transformation, progression
and metastasis involve the alteration of normal apoptotic pathways.
Suh Hye Won(Ph.D. student))
B.S:Duksung Women’s Univ.(Pharmacy)
M.S.:Hanyang Univ.(Cell biology)
Choi Ko Woon(Ph.D. student)
B.S:The Catholic Univ.(Cell biology)
M.S.:Sung Kyun Kwan Univ.(Pharmacy)